THE PHARMACOLOGIC ACTIVITY OF N-METHYL--CYCLOHEXYLISOPROPYLAMINE HYDROCHLORIDE

¹ Pharmacological Research Laboratory, Frederick Stearns and Co., Division of Sterling Drug Inc., Detroit, Michigan

1. Racemic N-methyl--cyclohexylisopropylamine HCl has about two-thirds of the pressor activity of its phenyl analogue (racemic desoxyephedrine HCl).

2. 1-N-Methyl--cyclohexylisopropylamine HCl is more pressor and more excitatory on the central nervous system than is the d-isomer.

3. d-N-Methyl--phenylisopropylamine HCl is more pressor and more excitatory on the central nervous system than is the l-isomer.

4. All the isomers of N-methy1--cyclohexylisopropylamine HCl and N-methyl --phenylisopropylamine HCl were found to have the same acute toxicity in mice.

5. Racemic Neo-Synephrine HCl is approximately twenty-five times more pressor than racemic N-methyl--cyclohexylisopropylamine HCl, approximately seventeen times more pressor than N-methyl--phenylisopropylamine HCl and is approximately one-sixth as toxic.