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Journal of Pharmacology And Experimental Therapeutics, Vol. 89, Issue 3, 368-378, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

3', 5'-DIBROMOSULFANILANILIDE: TOXICITY, ABSORPTION, AND METABOLISM

EVAN W. McCHESNEY 1

1 Sterling-Winthrop Research Institute, Rensselaer, N. Y.

The solubility, toxicity, absorption and metabolism of 3',5'-dibromosulfanilanilanilide have been studied. The compound is poorly absorbed in most species, particularly man, and therapeutic blood levels have not been achieved except in the rat. The excretion of the drug in man is preceded by a process of conjugation with a carbohydrate radical and since this occurs in the N4 position, the resulting compound is practically devoid of antibacterial action. The conjugation appears to be of a type not previously reported. The exact structure of the conjugate has not been established.

Submitted on January 11, 1947






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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.