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Journal of Pharmacology And Experimental Therapeutics, Vol. 89, Issue 3, 320-324, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

ON THE MECHANISM OF PARALYSIS RESULTING FROM TOXIN OF CLOSTRIDIUM BOTULINUM

The Action of The Toxin on Acetylcholine Synthesis and on Striated Muscle

CLARA TORDA 1 and HAROLD G. WOLFF 1

1 New York Hospital and the Departments of Medicine (Neurology) and Psychiatry, Cornell University Medical College, New York, N. Y.

1. The effects of toxins of Cl. botulinum, Types A and B, on the synthesis of acetylcholine and on the responsiveness of striated muscle to acetylcholine were investigated.

2. The synthesis of acetylcholine decreased in the presence of the toxins.

3. The responsiveness of striated muscle to acetylcholine was not modified by low concentrations of the toxins (from 1 to 100 LD50 per 100 cc. Ringer's solution) and was moderately increased by high concentrations of the toxins (10,000 LD50 per 100 cc.).

4. It is suggested that decreased acetylcholine synthesis, as far as it is relevant to myoneural function, is mainly responsible for the "functional paralysis" observed in animals affected by the toxins of Cl. botulinum.

Submitted on December 30, 1946




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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.