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Journal of Pharmacology And Experimental Therapeutics, Vol. 89, Issue 3, 297-305, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

THE PHARMACOLOGY OF VASODEPRESSOR COMPOUNDS STRUCTURALLY RELATED TO THE SYMPATHOMIMETIC AMINES

A. M. LANDS 1, E. E. RICKARDS 1, V. L. NASH 1, and K. Z. HOOPER 1

1 Pharmacological Research Laboratory, Frederick Stearns and Company, Division of Sterling Drug Inc., Detroit, Michigan

1. The pressor potency of 1-(p-hydroxyphenyl)-2-aminoethane (tyrarnine) is diminished by the addition of an hydroxyl group to the beta-carbon and by the addition of a methyl group to the nitrogen.

2. The replacement of one of the hydrogens of the amino group of 1-(p-hydroxyphenyl)-2-aminoethanol by ethyl, isopropyl, secondary butyl or tertiary butyl groups results in compounds that are strongly depressor in action. similar substitution by n-propyl, n-butyl and isobutyl groups results in compounds which exert only transient depressor action.

3. The presence of an alcoholic hydroxyl on the beta-carbon appears to be necessary for this action.

4. Those compounds which cause a prolonged fall in blood pressure are also most active in bringing about inhibition in those organs inhibited by epinephrine

Submitted on November 27, 1946




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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.