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Journal of Pharmacology And Experimental Therapeutics, Vol. 89, Issue 3, 247-255, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

PHARMACOLOGICAL PROPERTIES OF ANTIHISTAMINE DRUGS, BENADRYL, PYRIBENZAMINE AND NEOANTERGAN

T. R. SHERROD 1, EARL R. LOEW 1, and H. F. SCHLOEMER 1

1 Department of Pharmacology, University of Illinois College of Medicine, Chicago

1. In dogs, equal doses of Benadryl, Pyribenzamine and Neoantergan were of the same effectiveness in antagonizing the depressor action of histamine, whereas the depressor action of acetylcholine was diminished only by Benadryl.

2. Pyribenzamine and Neoantergan may be more specific than Benadryl as regards antihistamine action, and are more potent relative to prevention of fatal histamine shock in guinea pigs. Benadryl exerted an antispasmodic action on the dog's intestine but not on the uterus and all the compounds diminished the spasmogenic action of histamine on the duodenum and uterus. Pyribenzamine and Neoantergan contracted the duodenum and uterus.

3. These antihistamine compounds enhanced the pressor response to epinephrine, the phenomenon being unrelated to a cardiac vagal blocking action.

Submitted on December 16, 1946




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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.