JPET Celsis microsomes equal better data

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Journal of Pharmacology And Experimental Therapeutics, Vol. 89, Issue 3, 234-246, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

COMPARATIVE ACTIVITY OF VARIOUS ANTIHISTAMINIC SUBSTANCES TOWARDS THE VASODEPRESSOR RESPONSE TO HISTAMINE

DAVID FIELDING MARSH 1 and ALBERT JAMES DAVIS Jr. 1

1 Department of Pharmacology, West Virginia University School of Medicine, Morgantown, W. Va.

The most active known antihistaminic agents have been tested for their ability to antagonize the depressor response of histamine on blood pressure in the dog, and their activity compared on a quantitative basis.

The three most promising available compounds, Pyribenzamine, Benadryl, and dimethylaminoethylphenyl-agr-thienylglycolate (0-2, 315) were shown to he able to antagonize the various cardiovascular effects of histamine in the guinea pig, rat, rabbit and cat.

Submitted on December 14, 1946






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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.