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Journal of Pharmacology And Experimental Therapeutics, Vol. 89, Issue 3, 222-226, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

ANESTHESIA

XXIV. The Effect of Cholesterol on Pentothal and Ether Anesthesia

FARSON B. DE CAMP 1, C. JELLEFF CARR 1, and JOHN C. KRANTZ JR. 1

1 Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, Maryland

1. The intravenous or intraperitoneal injection of cholesterol in the rabbit and the dog has been shown to intensify the anesthetic action of pentothal sodium.

2. Cholesterol injections lengthened the anesthetic syndrome in the rabbit produced by subcutaneous injections of ether.

3. Cholesterol injections produced no significant effect upon the anesthetic syndrome in the dog, using the inhalation technic.

4. Cholesterol injections diminished the ether induction period in mice.

Submitted on November 21, 1946






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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.