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Journal of Pharmacology And Experimental Therapeutics, Vol. 89, Issue 2, 125-130, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

THE CHRONIC TOXICITY AND PATHOLOGY OF THIOURACIL IN CATS

w. T. McCLOSKY 1, R. D. LILLIE 1, and M. I. SMITH 1

1 Division of Physiology and Laboratory of Pathology, National Institute of Health, Bethesda, Maryland

Thiouracil fed to cats in doses of up to 300 mg. per kg. per day for a period of 7 to 8 months had no demonstrable toxic effects, it had no appreciable effect on

the hematocrit, it had an inconstant effect on the hemoglobin, no effect on plasma bilirubin, and only slight effect in delaying the rate of elimination of intravenously injected bilirubin in about half of the animals. Daily doses of 500 mg. per kg. in three cats proved fatal in 38 to 90 days.

The significant pathologic findings appear to be necrosis and scarring in the reticular zone of the adrenal cortex, moderate fatty degeneration in the liver, with glycogen preservation, atrophy of the thyroid and of the seminiferous tubules of the testis, hyperplasia of testicular interstitial cells and a moderate hepatic and splenic hemosiderosis.

Submitted on October 30, 1946




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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.