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Journal of Pharmacology And Experimental Therapeutics, Vol. 89, Issue 2, 109-114, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

THE ANTIDOTAL ACTION OF p-AMINOPROPIOPHENONE WITH OR WITHOUT SODIUM THIOSULFATE IN CYANIDE POISONING

CHARLES L. ROSE 1, JOHN S. WELLES 1, ROBERT D. FINK 1, and K. K. CHEN 1

1 Lilly Research Laboratories, Eli Lilly and Company, Indianapolis 6

1. Dogs poisoned by subcutaneous injection of sodium cyanide can be saved by intravenous administration of p-aminopropiophenone, provided the dose of the poison is under 4 LD50's.

2. Potentiation of antidotal action against cyanide occurs when p-aminopropiophenone and sodium thiosulfate are successively injected by vein. The amount of sodium cyanide detoxified by this combination is about the same as that by sodium nitrite and sodium thiosulfate.

Submitted on October 14, 1946




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Studies of the Pharmacokinetics and Metabolism of 4-Aminopropiophenone (PAPP) in Rats, Dogs and Cynomolgus Monkeys
Human and Experimental Toxicology, January 1, 1991; 10(5): 365 - 374.
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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.