JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by RAAB, W.
Right arrow Articles by HUMPHREYS, R. J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by RAAB, W.
Right arrow Articles by HUMPHREYS, R. J.
Journal of Pharmacology And Experimental Therapeutics, Vol. 89, Issue 1, 64-76, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

DRUG ACTION UPON MYOCARDIAL EPINEPHRINE-SYMPATHIN CONCENTRATION AND HEART RATE (NITROGLYCERINE, PAPAVERINE, PRISCOL, DIBENAMINE HYDROCHLORIDE)

W. RAAB M.D.1 and R. J. HUMPHREYS B.S.1

1 From the Division of Experimental Medicine, University of Vermont, College of Medicine, Burlington, Vermont

Injection of epinephrine or acetylcholine in atropinized cats, faradic stimulation of the stellate ganglia in cats with the adrenals tied, and faradic stimulation of the splanchnic nerves were found to be followed both by an accumulation of epinephrine and epinephrine-like catechol compounds (probably sympathin) in the heart muscle, and by cardiac acceleration.

Simultaneous intravenous administration of nitroglycerine, papaverine, priscol and dibenamine hydrochloride abolished those types of adreno-sympathetic cardiac acceleration against which they were tested, either partially or completely.

Nitroglycerine and priscol interfered only to a moderate extent with the accumulation of epinephrine-like material in the myocardium; papaverine inhibited it markedly; dibenamine hydrochloride prevented it completely during stimulation of the stellate ganglia. Thus, the mode of antagonistic action against adreno-sympathetic cardiac acceleration appears to be of a different nature in these drugs.

The anti-epinephrine-sympathin effects of nitroglycerine and papaverine regarding myocardial function suggest that the therapeutic action of these drugs in angina pectoris is not due to coronary dilatation alone but also to a specific counteraction against the myocardial metabolic effects of an excess influx of adreno-sympathogenic epinephrine in the heart.

Submitted on October 4, 1946




This article has been cited by other articles:


Home page
 ANGIOLOGYHome page
G. H. Whipple
Papaverine as an Antiarrhythmic Agent
Angiology, November 1, 1977; 28(11): 737 - 749.
[PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.