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Journal of Pharmacology And Experimental Therapeutics, Vol. 89, Issue 1, 14-17, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF SODIUM CAPRYLATE ON THE CARDIAC OUTPUT OF THE ISOLATED FROG HEART

HENRY W. ELLIOTT 1, HELEN M. KIPPLE 1, and VICTOR E. HALL 1

1 Department of Physiology, School of Medicine, Stanford University

Sodium caprylate added to glucose-Ringers in concentrations between 0.000625 and 0.025 molar has a stimulating effect on the cardiac output of the isolated frog heart under conditions of constant venous pressure and peripheral resistance. The effect is much more marked in hearts that have failed than on fresh hearts. The effect is brought about by an increase in stroke volume apparently by improving the contractility of the muscle.

Submitted on September 11, 1946






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Copyright © 1947 by the American Society for Pharmacology and Experimental Therapeutics.