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Journal of Pharmacology And Experimental Therapeutics, Vol. 89, Issue 1, 1-13, 1947
Copyright © 1947 by American Society for Pharmacology and Experimental Therapeutics

TESTS OF 2,3-DIMERCAPTOPROPANOL AND RELATED DITHIOLS. FOR DECONTAMINATION OF LEWISITE ON HUMAN SKIN

JOHN F. THOMSON 1, JOSEPH SAVIT 1, and EUGENE GOLDWASSER 1

1 The Department of Anatomy and the Toxicity Laboratory, University of Chicago

1. The vesicant action of 0.1 mg. of lewisite on human skin can be prevented more effectively by treatment with 2,3-dimercaptopropanol (BAL) than by most of the other dithiols tested.

2. The effectiveness of BAL and other dithiols is dependent largely upon (1) the dose of lewisite used, (2) the interval between contamination and decontamination, (3) the concentration of the dithiol in the vehicle, and, especially, (4) the temperature and relative humidity of the immediate envioronment of the test subject.

3. A number of water-soluble derivatives of BAL have been tested, several of which are nearly as effective as BAL.

4. Monothiols, thiourea derivatives, and thioacids were of little effect in the decontamination of lewisite on human skin.

Submitted on June 12, 1946






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