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Journal of Pharmacology And Experimental Therapeutics, Vol. 88, Issue 4, 382-387, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics


RESPONSE OF BONE MARROW EXPLANTS TO LIVER EXTRACT PREPARATIONS

K. E. ARMBRUST 1 and H. D. BETT 1

1 Connaught Medical Research Laboratories, University of Toronto, Toronto, Canada

The migration of cells from explants of guinea pig bone marrow has been studied. This migration appears to be controlled by the addition of extracts containing the anti-pernicious anemia substance. In 90 per cent of the tests, the relationship between concentration and migration could be expressed as a linear function. This test may be useful in the qualitative testing of liver extracts for anti-pernicious anemia activity.

Submitted on July 16, 1946







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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.