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Journal of Pharmacology And Experimental Therapeutics, Vol. 88, Issue 4, 333-337, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF ORAL ADMINISTRATION OF DDT ON THE METABOLISM OF GLUCOSE AND PYRUVIC ACID IN RAT TISSUES

BERNARD J. JANDORF 1, HERBERT P. SARETT 1, and OSCAR BODANSKY 1

1 Biochemistry Section, Medical Division, Chemical Warfare Service, Edgewood Arsenal, Md.

1. Daily administration of 50 mg. DDT per kg. in corn oil to rats by stomach tube for 30-50 days produced, at a time when the animals were free from symptoms of acute intoxication, no change in the oxygen consumption, aerobic and anaerobic lactic acid production of cerebral and cerebellar homogenates and in the oxygen consumption of liver slices, in the presence of added glucose. Aerobic and anaerobic lactic acid production in liver slices was depressed to a small but statistically significant degree.

2. Rats treated as before for 70-100 days showed no significant change in the respiration rate with pyruvic acid as substrate, or in the utilization of pyruvic acid, by cerebral and cerebellar homogenates and by liver, kidney cortex and heart slices.

3. When DDT was administered to rats by incorporation in their diet for periods of 1-10 days, liver slices from such rats showed significant increase in the oxygen consumption above that of control animals.

Submitted on August 2, 1946






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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.