JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by RIKER, W. F.
Right arrow Articles by CATTELL, M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by RIKER, W. F., JR.
Right arrow Articles by CATTELL, M.
Journal of Pharmacology And Experimental Therapeutics, Vol. 88, Issue 4, 327-332, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON DDT (2,2 BIS-PARACHLORO PHENYL-1,1,1, TRICHLORETHANE): EFFECTS ON OXIDATIVE METABOLISM

WALTER F. RIKER JR. 1, VIRGINIA R. HUEBNER 1, SIGWIN B. RASKA 1, and McKEEN CATTELL 1

1 Department of Pharmacology, Cornell University Medical College, New York City

1. In rats poisoned with DDT there is an increase in the total metabolic rate.

2. The increased metabolic rate is reflected in an increase in food and water intake and a slight loss in body weight.

3. The oxygen uptake of liver slices from DDT poisoned rats is increased.

4. In advanced DDT poisoning, slices taken from parts of the liver showing gross abnormalities have instead of an increased oxygen uptake a reduction below the control values.

5. The oxygen consumption of sartorius muscles from frogs poisoned with DDT is increased.

6. A significant increase in the respiration of the brain tissue has not been demonstrated.

7. A known metabolite of DDT, di(p-chlorophenyl) acetic acid has been shown not to be responsible for the characteristic actions of DDT.

Submitted on August 2, 1946






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.