NERVOUS SYSTEM CHANGES PRODUCED IN DOGS BY CHOLINE AND CARBAMYL CHOLINE

¹ Departments of Pharmacology and Pathology, University of Arkansas, Little Rock

Hyperchromic anemia was produced in six dogs by the regular daily administration of choline chloride and/or carbamyl choline. Definite changes in the nervous system were also produced by these drugs. In the acute phase the lesions were characterized by multiple hemorrhages in the grey substance of the brain and spinal cord, and by a diffuse gliosis and acute neurone changes. After recovery from drug treatment, the lesions were characterized by perivascular gliosis, glial nodules, diffuse ghial scar formation, and neurone depletion. The similarities and differences between these central nervous system changes and those described in pernicious anemia are mentioned. The possible etiological factors responsible for these changes are discussed briefly.