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Journal of Pharmacology And Experimental Therapeutics, Vol. 88, Issue 2, 136-141, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

THE ANTAGONISM OF TETRAETHYLAMMONIUM AGAINST HEART DEPRESSANTS

O. LOEWI 1

1 Department of Pharmacology, New York University College of Medicine

1. Tetraethylammonium in high concentrations has an action by itself. It increases the contractions of the frog's heart.

2. It antagonizes in concentrations below those augmenting the heart beats, the depressant actions not only of vagomimetic quarternary bases but also those of tertiary bases as pilocarpine and arecoline and of potassium.

3. Possible mechanisms of these antagonisms are discussed.

Submitted on June 6, 1946




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E. J. HILL, J. M. HAMMER, H. C. SALTZSTEIN, and C. D. BENSON
TETRAETHYLAMMONIUM CHLORIDE IN EXPERIMENTAL VASCULAR INJURIES OF LIMB, BOWEL AND HEART
Arch Surg, September 1, 1949; 59(3): 527 - 541.
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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.