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Journal of Pharmacology And Experimental Therapeutics, Vol. 88, Issue 1, 99-108, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

ARSINE POISONING, MODE OF ACTION AND TREATMENT

C. J. KENSLER , J. C. ABELS , and C. P. RHOADS

1. "Fat soluble" mono and dithiols have been found to prevent the lysis of erythrocytes by arsine in vitro when they are added five minutes after the cells have been exposed to arsine.

2. Certain dithiols will protect tissue respiration from inhibition by arsine and arsenite.

3. Several dithiols are effective in saving the lives of rabbits, dogs and monkeys given doses of arsine ca. the L.D.100.

4. 2,3-dimercaptopropyl ethyl ether has been shown to be effective in the treatment of arsine poisoning in rabbits, monkeys and dogs when administered either intramuscularly or percutaneously.

5. The effectiveness of this compound in the treatment of arsine poisoning falls off rapidly as the time interval between exposure and treatment is increased.

6. Because of the possible danger of central nervous system damage caused by the injection of this compound into a vein, the percutaneous route of administration is to be preferred.

Submitted on June 3, 1946




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The Effects of Sulfur, Thiol, and Thiol Inhibitor Compounds on Arsine-Induced Toxicity in the Human Erythrocyte Membrane
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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.