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Journal of Pharmacology And Experimental Therapeutics, Vol. 88, Issue 1, 47-57, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

PHARMACOLOGICAL AND CHEMOTHERAPEUTIC PROPERTIES OF 3,4-DIMETHYL-5-SULFANILAMIDO-ISOXAZOLE

R. J. SCHNITZER 1, R. H. K. FOSTER 1, N. ERCOLI 1, G. SOO-HOO 1, C. N. MANGIERI 1, and M. D. ROE 1

1 From the Chemotherapy and Pharmacology Laboratories of the Research Department of Hoffmann-La Roche, Inc., Nutley, N. J.

1. 3,4-Dimethyl-5-sulfanilamido-isoxazole (Nu-445) and its salts possess remarkably good solubility over a wide pH range particularly in the physiologically important range of pH 6.0-8.0.

2. Due to this solubility no kidney damage was produced after prolonged treatment of rats and rabbits with high doses of the compound.

3. The low toxicity of the new compound and its chemotherapeutic activity in vitro and in experimental infections with the most important representatives of gram positive and gram negative pathogenic micro-organisms indicate that that therapeutic potentialities of the compound compare favorably with those of known and clinically useful sulfonamides.

Submitted on June 16, 1946




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 Arch Intern MedHome page
F. A. SVEC, P. S. RHOADS, and J. H. ROHR
A NEW SULFONAMIDE (GANTRISIN(R)) Studies on Solubility, Absorption and Excretion
Arch Intern Med, January 1, 1950; 85(1): 83 - 90.
[Abstract] [PDF]


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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.