JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by KOSTER, R.
Right arrow Search for Related Content
PubMed
Right arrow Articles by KOSTER, R.
Journal of Pharmacology And Experimental Therapeutics, Vol. 88, Issue 1, 39-46, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

SYNERGISMS AND ANTAGONISMS BETWEEN PHYSOSTIGMINE AND DI-ISOPROPYL FLUOROPHOSPHATE IN CATS

RUDOLF KOSTER 1

1 Department of Pharmacology, Cornell University Medical College

1. A small dose of physostigmine given to cats protects against the fatal action of a subsequent dose of DFP (di-isopropyl fluorophosphate).

2. Repeated injections of physostigmine do not significantly increase tolerance.

3. DFP results in a long lasting increase in the susceptibility of cats to the lethal action of physostigmine. This result of DFP is much less pronounced in cats protected by physostigmine.

4. The cholinesterase activity of the serum from animals pre-treated with physostigmine shows a smaller reduction than serum from animals receiving DFP alone, and recovery is more rapid.

Submitted on May 16, 1946




This article has been cited by other articles:


Home page
 Br Med BullHome page
A. A. Weinbroum
Pathophysiological and clinical aspects of combat anticholinesterase poisoning
Br. Med. Bull., April 21, 2005; 72(1): 119 - 133.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.