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Journal of Pharmacology And Experimental Therapeutics, Vol. 88, Issue 1, 34-38, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

ANTIDOTES TO POISONING BY DI-ISOPROPYL FLUOROPHOSPHATE IN CATS

WALTER MODELL and STEPHEN KROP

1. In cats atropine given before or after DFP abolished the "muscarinic" symptoms, reduces or abolishes the central excitant effects, and provides marked protection against the fatal action of DFP.

2. Magnesium controls the fibrillary twitches of skeletal muscle caused by DFP, but alone affords but slight protection against the fatal action of DFP.

3. A considerable further degree of protection against DFP is afforded by the simultaneous use of magnesium and atropine.

4. The results indicate that DFP causes death by two mechanisms, one of which is blocked by atropine, the other brought on by larger doses is blocked by magnesium.






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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.