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Journal of Pharmacology And Experimental Therapeutics, Vol. 88, Issue 1, 23-26, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE OCULAR REACTIONS OF RABBITS TO DI-ISOPROPYL FLUOROPHOSPHATE

ROY O. SCHOLZ M.D.1

1 From the Wilmer Ophthalmological Institute of the Johns Hopkins University and Hospital

1. No permanent ocular lesions were found in rabbits when an almost lethal dose or repeated small doses were applied to the eyes.

2. Local application to rabbits' eyes of di-isopropyl fluorophosphate vapor or solution causes intense miosis, lacrimation, transient increase in intraocular pressure.

3. 1.4 mgm./kg. applied to a rabbit's eye is lethal.

4. Atropine applied before di-isopropyl fluorophosphate prevents the development of the miosis; applied after the drug, it relaxes pupilary contraction.

Submitted on May 11, 1946






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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.