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Journal of Pharmacology And Experimental Therapeutics, Vol. 88, Issue 1, 14-22, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

DIGITALIS III

THE RELATIONSHIP BETWEEN THE POTENCY AND BALJET REACTION OF THE GLYCOSIDES OF DIGITALIS

FREDERICK K. BELL 1 and JOHN C. KRANTZ JR. 1

1 Medical School, Department of Pharmacology University of Maryland, Baltimore, Md.

1. The relative intensities of the color reaction of solutions of seven digitalis glycosides toward alkaline picrate solutions have been determined. These glycosides are lanatosides A, B, and C, digoxin, digitoxin, gitoxin, and gitalin.

2. Confirming earlier work, the color intensities produced by the purpurea glycosides parallel the cardiotonic activity. This relationship does not hold in the case of the lanata glycosides and therefore, mixtures of these glycosides cannot be assayed by this color intensity.

3. An explanation has been offered to account for the differences in reactivity among the purpurea glycosides and digoxin based upon the supposition of the formation of isomers which are inactive. On the same basis, an explanation has been given for the observed divergence from Beer's law of the Baljet color reaction with these glycosides.

Submitted on May 9, 1946




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E. M. K. GEILING, F. E. KELSEY, B. J. MCINTOSH, and A. GANZ
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Science, November 19, 1948; 108(2812): 558 - 559.
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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.