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Journal of Pharmacology And Experimental Therapeutics, Vol. 87, Issue 4, 414-420, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

THE ACUTE TOXICITY OF DI-ISOPROPYL FLUOROPHOSPHATE

RICHARD G. HORTON 1, GEORGE B. KOELLE 1, BERNARD P. McNAMARA 1, and HARRY J. PRATT 1

1 From the Toxicity and Pharmacology Sections, Medical Division, Edgewood Arsenal, Maryland

1. The cholinergic signs observed in normal unanesthetized mice, rats, rabbits, dogs and cats after administration of di-isopropyl fluorophosphate (DFP) by different routes of administration have been described briefly.

2. The acute median lethal doses of DFP after intravenous administration in 52 rabbits, 38 dogs and 83 cats; subcutaneous injection in 50 mice, intramuscular injection in 60 rats; and oral administration in 45 mice and 50 rabbits have been determined.

3. The LD50's and the standard errors for the several series of experiments were as follows:

[See table in the PDF file]

Submitted on May 4, 1946






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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.