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Journal of Pharmacology And Experimental Therapeutics, Vol. 87, Issue 4, 389-391, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

METABOLIC STUDIES ON beta-CYCLOHEXYLETHYLAMINES

FRED H. SNYDER 1 and FRED W. OBERST 1

1 From the Department of Biochemistry, Research Laboratories, The Wm. S. Merrell Company, Cincinnati, Ohio

1. agr-Methyl substitution of beta-cyclohexylethylamine prevents oxidation of the compound in the presence of amine oxidase preparations, and inhibits to a significant extent its destruction following subcutaneous administration to white rats.

2. beta-Cyclohexylethylamine and its beta-methyl- and N-methyl-beta-methyl-derivates are oxidized by amine oxidase, and are almost completely destroyed by the intact animal.

Submitted on May 3, 1946






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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.