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Journal of Pharmacology And Experimental Therapeutics, Vol. 87, Issue 4, 382-388, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF ALLOXAN, SENECIONINE, SULFADIAZINE, AND THIOURACIL IN THE HAMSTER

PAUL N. HARRIS 1, ROBERT C. ANDERSON 1, and K. K. CHEN 1

1 From the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis 6, Indiana

1. Intravenous administration of appropriate single doses of alloxan to the hamster leads to necrosis of renal tubules, and to injury of the beta cells of the pancreatic islands with development of very high blood sugar levels.

2. Intravenous administration of single doses of senecionine to the hamster results in development of periportal necrosis of the liver.

3. Prolonged administration of sulfadiazine to the hamster does not result in severe renal injury, probably because the concentration of the conjugated form in the blood is so low. Slight hypertrophy of the thyroid and decrease of its colloid can be demonstrated.

4. Addition of thiouracil to the hamster's diet results in hypertrophy of the thyroid epithelium and diminution of colloid, but the effect seems to be less intense than in the rat.

Submitted on May 3, 1946




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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.