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Journal of Pharmacology And Experimental Therapeutics, Vol. 87, Issue 4, 360-363, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

BLOOD PLASMA ATABRINE LEVELS OBTAINED WITH SUPPRESSIVE AND THERAPEUTIC DOSES OF ATABRINE DIHYDROCHLORIDE

PAUL K. SMITH 1, BARBARA N. GALLUP 1, and LOUISE J. CAIN 1

1 From the Department of Pharmacology and Biochemistry, AAF School of Aviation Medicine, Randolph Field, Texas

1. The blood plasma levels of subjects receiving the same dose of atabrine are extremely variable.

2. The group average plasma levels obtained are approximately proportional to the dose used.

3. With constant daily doses, four to five weeks are required to reach constant mean plasma levels. Similar plasma levels are reached in two weeks when the dose is doubled during the first week.

4. With low plasma levels of atabrine a reduction to one-half occurs in approximately two weeks after administration of the drug ceases. With a large dose and high plasma levels the reduction is more rapid.

5. Moderate doses of sodium bicarbonate or of ethyl alcohol do not affect the plasma levels.

Submitted on March 27, 1946






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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.