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Journal of Pharmacology And Experimental Therapeutics, Vol. 87, Issue 4, 350-359, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

THE PROTECTIVE ACTION OF ATABRINE AGAINST CHLOROFORM-ADRENALINE VENTRICULAR FIBRILLATION

K. I. MELVILLE 1

1 Department of Pharmacology, McGill University, Montreal, Canada

It is shown that intravenous injections of atabrine hydrochloride can prevent the development of ventricular fibrillation following injection of adrenaline during chloroform administration in dogs anesthetized with pentobarbital. This protective action of atabrine is also demonstrable after atropinization or vagotomy.

Electrocardiograms taken during the rise in blood pressure following injection of adrenaline in the pentobarbitalized dog, show characteristic early diphasic alterations in both P and T waves. These alterations are accentuated if chloroform is being administered, but under similar conditions are antagonized by atabrine.

The possibility is suggested that this protective action of atabrine is primarily a coronary phenomenon. Thus, atabrine (a coronary dilator agent) might offset either an initial reduction in coronary blood flow or some impairment in myocardial nutrition, induced by adrenaline under the conditions described.

Submitted on March 25, 1946




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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.