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Journal of Pharmacology And Experimental Therapeutics, Vol. 87, Issue 4, 343-349, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

CHANGES IN THE LEUCOCTYE PICTURE IN EXPERIMENTAL TRYPANOSOMIASIS BY ADMINISTRATION OF NEOSTIBOSAN AND NEOSTAM

OKECHUKWU IKEJIANI 1 and LAWRENCE S. MAUTNER 1

1 From the Department of Pathology and Bacteriology, University of Toronto

1. In rats which show no resistance to infection with Trypanosoma equiperdum, the most characteristic change in the leucocyte picture is a decrease in lymphocyte per-centage, increase in polymorphonuclear neutrophil per-centage and a decrease in monocyte per-centage.

2. Rats infected with T. equiperdum and treated with neostibosan or neostam showed increased monocyte per-centage, decreased polymorphonuclear neutrophil per-centage and increased lymphocytes, after treatment.

3. It is suggested that the increased monocytes play adjunctive role in respect to the drugs (neostibosan and neostam) by completing the destruction of trypanosomes after they have been rendered vulnerable by the drugs.

Submitted on March 21, 1946






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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.