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Journal of Pharmacology And Experimental Therapeutics, Vol. 87, Issue 3, 273-280, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

THE BLOCKING EFFECT OF TETRAETHYLAMMONIUM ION ON THE SUPERIOR CERVICAL GANGLION OF THE CAT

GEORGE H. ACHESON 1 and SERGIO ARANHA PEREIRA 1

1 Deportment of Pharmacology, Harrard Medical School, Boston

In cats under dial anesthesia the effects of tetraethylarnmonium bromide were studied on the nictitating membrane and its innervation. This substance does not materially affect the membrane itself or its postganglionic nerves. It produces a block of transmission of nerve impulses across the superior cervical ganglion. The ganglionic stimulating action of acetyicholine is also blocked, but that of potassium ion is not. Unlike curare, many other quaternary ammonium compounds, and nicotine, tetraethylammonium ion has no actions except this specific ganglionic blocking action over a wide range of doses.

Submitted on April 17, 1946




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Science, January 7, 1949; 109(2819): 16 - 16.
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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.