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Journal of Pharmacology And Experimental Therapeutics, Vol. 87, Issue 3, 237-255, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE PHARMACOLOGY OF SALICYLATES

PAUL K. SMITH 1, HELEN L. GLEASON 1, C. G. STOLL 1, and S. OGORZALEK 1

1 Department of Pharmacology and Biochemistry, AAF School of Aviation Medicine, Randolph Field, Texas

1. Colorimetric methods have been developed for the determination in urine of free salicylate, salicyluric acid and total salicylates.

2. Most of the salicylate in human plasma is bound to the non-diffusible components, presumably plasma proteins.

3. Even at high plasma salicylate concentrations very little salicylate is in human erythrocytes.

4. After the oral administration of aspirin to human subjects or oral or intravenous administration to dogs the only detectable form of salicylate in the plasma is free salicylate.

5. The administration of sodium bicarbonate along with salicylates results in lower plasma levels than when the salicylate alone is given.

6. The administration of sodium bicarbonate to patients receiving sodium salicylate results in an increased excretion of free salicylate, with the renal clearances of free salicylate increasing rapidly above pH 7 in the urine.

Submitted on March 27, 1946




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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.