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Journal of Pharmacology And Experimental Therapeutics, Vol. 87, Issue 3, 214-219, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

AGGREGATION AS A FACTOR INFLUENCING THE TOXICITY OF SYMPATHOMIMETIC AMINES IN MICE

M. R. A. CHANCE 1

1 Biochemical Department, Glaxo Laboratories, Ltd., Greenford, Middlesex

1. Aggregation influences the toxicity of sympathomimetic amines in mice.

2. As the area per mouse increases, the toxicity decreases for mice confined in a group.

3. If the area per mouse is kept. constant at approximately 50 sq. cm., the presence of [9] other mice markedly increases the toxicity of these drugs.

4. Environmental temperature greatly influences the degree of mutual excitation and thus modifies the effect of aggregation on toxicity.

Submitted on January 24, 1946




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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.