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Journal of Pharmacology And Experimental Therapeutics, Vol. 87, Issue 1, 38-41, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF SENECIONINE ON THE MONKEY

K. G. WAKIM 1, PAUL N. HARRIS 1, and K. K. CHEN 1

1 From Indiana Universiy Medical Center, and the Lilly Research Laboratories, Indianapolis

Intravenous administration of senecionine to 4 rhesus monkeys led to the development of extensive necrosis of the liver of 3 of the animals, and to fatty degeneration of the kidneys of all 4. Associated with the hepatic necrosis were a steady increase of prothrombin time and a progressive elevation of the serum bilirubin.

Submitted on February 14, 1946






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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.