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Journal of Pharmacology And Experimental Therapeutics, Vol. 87, Issue 1, 33-37, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

PYRUVIC ACID ANTAGONISM TO BARBITURATE DEPRESSION

B. A. WESTFALL 1

1 Department of Physiology and Pharmacology, University of Missouri, Columbia

Data on 64 rabbits anesthetized with pentobarbital sodium (40 mgm./kgm. intravenously) indicate that:

1. Epinephrine increases the blood sugar level and shortens the sleeping time.

2. Insulin decreases the blood sugar level and shortens the sleeping time.

3. Intravenous injection of pyruvic acid decreases the depth of depression, and shortens the sleeping time (as defined in this study), but does not alter materially total depression time in rabbits.

Submitted on February 11, 1946






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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.