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Journal of Pharmacology And Experimental Therapeutics, Vol. 87, Issue 1, 11-17, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

TOXICOLOGY OF 1,2-DICHLOROPROPANE (PROPYLENE DICHLORIDE)

II. INFLUENCE OF DIETARY FACTORS ON THE TOXICITY OF DICHLOROPROPANE

LEON A. HEPPEL 1, B. HIGHMAN 2, V. T. PORTERFIELD 3, and EVELYN G. PEAKE 4

1 Senior Assistant Surgeon, Industrial Hygiene Research Laboratory, National Institute of Health, U.S. Public Health Service, Bethesda, Maryland
2 Senior Assistant Surgeon (R), (Pathology Laboratory), Industrial Hygiene Research Laboratory, National Institute of Health, U.S. Public Health Service, Bethesda, Maryland
3 Assistant Chemist, Industrial Hygiene Research Laboratory, National Institute of Health, U.S. Public Health Service, Bethesda, Maryland
4 Industrial Hygiene Research Laboratory, National Institute of Health, U.S. Public Health Service, Bethesda, Maryland

(1) Weaning rats prepared for several weeks on low protein-choline deficient diets were more susceptible to the effects of inhalation exposures to 1,2-dichloropropane than were control rats on an adequate diet. This was true even in pairfeeding experiments.

(2) Supplements of choline did not appreciably increase the resistance of the choline deficient-protein deficient rats. dl-Methionine and the combination of l-cystine plus choline were quite effective.

(3) The pathological lesions found in exposed and control rats are described.






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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.