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Journal of Pharmacology And Experimental Therapeutics, Vol. 86, Issue 4, 336-338, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

TOXICITY OF CERTAIN HALOGEN SUBSTITUTED ALIPHATIC ACIDS FOR WHITE MICE

JAMES L. MORRISON 1

1 Department of Pharmacology, Emory University School of Medicine, Emory University, Georgia

The oral toxicity for mice of eight halogenated fatty acids increases in relation to the increase in molecular weight of the substituted halogen and decreases as the carbon chain is lengthened. In the case of four acids the LD50 of which could not be readily determined, substitution of halogen in the beta position markedly reduces the toxicity as does branching of the carbon chain.

Submitted on January 10, 1946




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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.