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Journal of Pharmacology And Experimental Therapeutics, Vol. 86, Issue 3, 294-296, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

THE RATE OF DISAPPEARANCE OF A MARIHUANA-ACTIVE SUBSTANCE FROM THE CIRCULATING BLOOD

S. LOEWE 1

1 Department of Pharmacology, Cornell University Medical College

The persistence in the blood stream of parahexyl, a synthetic marihuana active substance, was studied in dogs. Large doses were injected by vein, and the blood concentration was determined at varying intervals by assay of the ataxia action of blood extracts in test dogs. One to ten per cent of the injected dose was found circufating between two and eleven hours after the injection. In one animal about one per cent of an intravenous dose was recovered in the lungs after twenty hours.

Submitted on January 3, 1946






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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.