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Journal of Pharmacology And Experimental Therapeutics, Vol. 86, Issue 3, 284-286, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

ACUTE TOXICITY OF VASOPRESSOR AMINES

II. Comparative Data

MARSHALL R. WARREN 1 and HAROLD W. WERNER 1

1 Pharmacology Department. Research Laboratories, The Wm. S. Merrell Company, Cincinnati, Ohio

Comparative LD50 values are presented for seven vasopressor amines.

Vonedrine, Ephedrine, and Propadrine have a similar order of toxicity and constitute the low toxicity group. Vonedrine differs from the other two amines in this group in that it is less toxic following subcutaneous injection in older and heavier rats.

Tuamine, Amphetamine, Privine, and Neo-Synephrine are the most toxic of the amines. The two latter compounds have a comparatively high order of toxicity following intravenous injection in rabbits; and Privine is especially toxic for the rabbit following all modes of administration investigated. This compound however, is the least toxic of the four in this group following subcutaneous injection in rats and mice.

Submitted on December 5, 1945






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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.