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Journal of Pharmacology And Experimental Therapeutics, Vol. 86, Issue 3, 280-283, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

ACUTE TOXICITY OF VASOPRESSOR AMINES

I. Effect of Temperature

MARSHALL R. WARREN 1 and HAROLD W. WERNER 1

1 Pharmacology Department, Research Laboratories, The Wm. S. Merrelt Company, Cincinnati, Ohio

The acute subcutaneous toxicities in mice of Ephedrine, Propadrine, and Amphetamine were increased by the elevation of environmental temperature while those of Tuamine, Vonedrine, and Privine were not significantly altered. Intravenous administrations indicate these effects were not due to alterations in rates of absorption.

Ephedrine had a greater and more persistent temperature-raising action than Vonedrine following subcutaneous injection in rats, and Ephedrine toxicity was increased more than that of Vonedrine in this species. Thus, altered toxicity at different temperatures appears to be correlated with effects of the amines on body temperature.

Effects of environmental temperature on the toxicity of various vasopressor amines were modified by weight (age) of animals and the species employed.

Submitted on December 5, 1945






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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.