JPET Celsis microsomes equal better data

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Journal of Pharmacology And Experimental Therapeutics, Vol. 86, Issue 3, 258-263, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF SOME ACRIDINE COMPOUNDS ON THE GROWTH AND RESPIRATION OF E. COLI

TOM B. FERGUSON 1 and SILAS O. THORNE Jr. 1

1 Department of Physiology and Pharmacology. Duke University Medical School, Durham, N. C.

1) The order of activity of several acridine compounds on the growth of E. coli on a synthetic medium has been determined.

2) Certain of the compounds in concentrations comparable to those that produce bacteriostasis inhibit the oxidation of glucose, pyruvic acid, lactic acid, asparagin and oleic acid.

3) The order of activity on the oxidative reactions is, however, different from that on growth.

4) Riboflavin does not antagonize the bacteriostatic action of these compounds.

Submitted on November 16, 1945






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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.