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Journal of Pharmacology And Experimental Therapeutics, Vol. 86, Issue 3, 205-212, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

CERTAIN PERIPHERAL AND CENTRAL NERVOUS SYSTEM EFFECTS OF beta-DIETHYLAMINOETHYL PHENYL-agr-THIENYL-GLYCOLATE HCl AND PHARMACOLOGICALLY RELATED COMPOUNDS

BENEDICT E. ABREU 1 and ELIZABETH TROESCHER-ELAM 1

1 Division of Pharmacology and Experimental Therapeutics, University of California Medical School, San Francisco, California

beta-diethylaminoethyl phenyl-agr-thienylglycolate HCl, in comparison with other related compounds

(1) Effectively opposes the spasmogenic action of: A. Piocarpine on the intact colon and ileum of the anesthetized rabbit. B. Morphine on the intact colon of the monkey and dog.

(2) Produces marked cardiac acceleration in the morphine treated and untreated dog; in the monkey cardiac acceleration is not very marked and is less than after the administration of 1/10 the dose of atropine sulfate calculated on a weight basis.

(3) Produces signs of central nervous system activity resembling delirium in the dog but not in the monkey or rabbit when employed in spasmolytic dosage.

Submitted on July 20, 1945






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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.