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Journal of Pharmacology And Experimental Therapeutics, Vol. 86, Issue 2, 174-176, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

THE ANTAGONISM BETWEEN ATROPINE AND STRYCHNINE IN THE MOUSE

FRANK H. LONGINO 1 and RHEA S. PRESTON 1

1 Department of Physiology and Pharmacology of the Duke University Medical School, Durham, N. C.

1. Atropine in a dosage of 400 mgm./kgm. protects mice against 1.33 mgm./kgm. of strychnine.

2. The percentage of recoveries varies with the time interval between the injection of atropine and strychnine. It is maximal when this interval is one hour. Some protection is however obtained after an interval of 48 hours.

3. The significance of this is discussed.

Submitted on October 24, 1945






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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.