JPET Introducing ALZET?ew Model 2006 Pump

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Journal of Pharmacology And Experimental Therapeutics, Vol. 86, Issue 2, 129-137, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

THE RELATIONSHIP BETWEEN CHEMICAL STRUCTURE AND SPASMOLYTIC ACTION OF SOME NEW ANTICOLINERGIC ESTERS

A. M. LANDS 1, V. LORAINE NASH 1, and KATHRYN Z. HOOPER 1

1 Pharmacological Research Laboratory, Frederick Stearns and Company, Division of Sterling Drug Inc., Detroit, Michigan

1. Anticholinergic spasmolytic compounds may be obtained by replacing the hydrogen atoms of various aminoalkyl acetates by phenyl, cyclohexyl, agr-thienyl, or hydroxyl groups.

2. Highly active spasmolytic compounds are obtained with trisubstituted acetates wherein an hydroxyl group is combined with agr-thienyl, phenyl or cyclohexyl groups.

3. The unsubstituted acetates of these aminoalcohols are cholinergic (muscarinic).

Submitted on September 12, 1945






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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.