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Journal of Pharmacology And Experimental Therapeutics, Vol. 86, Issue 1, 1-6, 1946
Copyright © 1946 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF VARIOUS DRUGS ON EXPERIMENTAL ASTHMA PRODUCED IN GUINEA PIGS BY EXPOSURE TO ATOMIZED HISTAMINE

EARL R. LOEW 1, MARGARET E. KAISER 1, and V. MOORE 1

1 From the Division of Pharmacological Research, Parke, Davis and Company Research Laboratories, Detroit 32, Michigan

Trasentin, Pavatrine, and Syntropan failed to alleviate experimental asthma induced in guinea pigs by exposing them to atomized histamine. Effective antispasmodic drugs in order of decreasing potency were: epinephrine, Benadryl, Demerol, atropine, papaverine, and aminophylline. The effect of drugs in experimental asthma should assist in selecting those with selective antispasmodic action on various types of smooth muscle.

Under the experimental conditions employed, bronchoconstriction referable to inhalation of histamine was not diminished by ergotamine tartrate, the local anesthetics, Procaine and Nupercaine, or by respiratory depressants such as morphine and pentobarbital.

Physostigmine and ephedrine increased the severity of the experimental asthma.

Submitted on July 16, 1945




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F. M. RACKEMANN
ALLERGY: A Review of the Literature of 1946 and 1947
Arch Intern Med, May 1, 1948; 81(5): 696 - 745.
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Copyright © 1946 by the American Society for Pharmacology and Experimental Therapeutics.