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Journal of Pharmacology And Experimental Therapeutics, Vol. 85, Issue 4, 356-362, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON FACTORS INFLUENCING THE TOXICITY OF NICOTINE. THE EFFECTS OF WATER AND FOOD DEPRIVATION; DISTURBED LIVER FUNCTION AND RATE OF ADMINISTRATION

H. B. HAAG 1, P. S. LARSON 1, and J. K. FINNEGAN 1

1 Department of Pharmacology, Medical College of Virginia, Richmond

1. Water deprivation was found to increase the tolerance of mice and rabbits to intraperitoneally injected nicotine, but not to intravenously injected nicotine. Water deprivation in rats for similar periods did not alter their susceptibility to intraperitoneally injected nicotine.

2. Damage of the liver by exposure to carbon tetrachloride decreased the tolerance of mice to intraperitoneally administered nicotine.

3. The rate of administration of nicotine markedly affects its toxicity.

Submitted on September 28, 1945






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Copyright © 1945 by the American Society for Pharmacology and Experimental Therapeutics.