JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by CHEN, K. K.
Right arrow Articles by MAZE, N.
Right arrow Search for Related Content
PubMed
Right arrow Articles by CHEN, K. K.
Right arrow Articles by MAZE, N.
Journal of Pharmacology And Experimental Therapeutics, Vol. 85, Issue 4, 348-355, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

THE RESPONSE OF THE HAMSTER TO DRUGS

K. K. CHEN 1, CLARENCE E. POWELL 1, and NILA MAZE 1

1 From the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis 6, Indiana

The Syrian hamster has been studied with various drugs. The anesthetic doses of 3 well-known barbituric acid derivatives have been determined. This information will be useful for operative procedures in the laboratory.

The Syrian hamster is about twice as sensitive to strychnine as the mouse.

The blood pressure response of the Syrian hamster to acetylcholine and epinephrine is similar to that of other mammals. On the other hand, the hamster is relatively resistant to histamine and especially to anaphylactic reaction.

The isolated intestine and uterus of the Syrian hamster behave more like those of the rat towards autonomic drugs and smooth muscle stimulants.

The rectal temperature, blood sugar, blood pressure, heart rate, and respiratory rate of the normal adult Syrian hamster have been recorded.

Submitted on September 28, 1945






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1945 by the American Society for Pharmacology and Experimental Therapeutics.