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Journal of Pharmacology And Experimental Therapeutics, Vol. 85, Issue 4, 332-335, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

REACTION OF TISSUE ALDEHYDES WITH CERTAIN DRUGS

KURT A. OSTER 1 and JEAN G. OSTER 1

1 From the Research Laboratories of McKesson & Robbins, Inc., Bridgeport, Conn.

1. Twenty-four compounds were investigated for their possible chemical combination with tissue aldehydes, using frozen sections of rat kidneys as test material.

2. A theory that tissue aldehydes may serve as acceptor substances in the cell for certain drugs is advanced.

3. The similarity of the chemical reactions of tissue aldehydes and Kohn's metabolite B has been shown.

Submitted on August 30, 1945






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Copyright © 1945 by the American Society for Pharmacology and Experimental Therapeutics.