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Journal of Pharmacology And Experimental Therapeutics, Vol. 85, Issue 3, 283-287, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

THE SYMPATHOMIMETIC VASODILATING ACTION OF THE ALIPHATIC AMINES

RAYMOND P. AHLQUIST 1

1 Department of Pharmacology, University of Georgia School of Medicine, Augusta

1. The three aliphatic amines studied produce a depressor response in dogs which is due in part to peripheral vasodilation.

2. This vasodilation is produced in a manner similar to that of the aromatic sympathomimetic amines such as epinephrine.

3. The pressor action of these aliphatic amines is more or less completely blocked by ephedrine.

4. If these aliphatic amines are to be used clinically for their pressor effect not more than one dose should be used and they should probably not be used with ephedrine.

Submitted on August 17, 1945






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Copyright © 1945 by the American Society for Pharmacology and Experimental Therapeutics.