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Journal of Pharmacology And Experimental Therapeutics, Vol. 85, Issue 2, 198-201, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON CYCLOPROPANE IX

THE EFFECT OF PREMEDICATION WITH DEMEROL UPON THE HEART RATE, RHYTHM AND BLOOD PRESSURE IN DOGS UNDER CYCLOPROPANE ANESTHESIA

BENJAMIN H. ROBBINS 1

1 From the Department of Pharmacology, Vanderbilt University School of Medicine Nashville, Tennessee

1. An investigation of the blood pressure and electrocardiographic changes has been made in dogs anesthetized with cyclopropane after medication with Demerol.

2. In most dogs there is a reduction in heart rate and temporary fall in blood pressure after the intramuscular injection of 10 mg./kg. of Demerol.

3. The cardiac irregularities routinely observed during cyclopropane anesthesia after morphine premedication in dogs are not observed after Demerol premedication.

4. Demerol reduces the amount of cyclopropane necessary for the lighter planes of anesthesia.

Submitted on July 12, 1945






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Copyright © 1945 by the American Society for Pharmacology and Experimental Therapeutics.