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Journal of Pharmacology And Experimental Therapeutics, Vol. 85, Issue 2, 192-197, 1945
Copyright © 1945 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF ETHER, DIVINYL ETHER AND CYCLOPROPANE ANESTHESIA UPON THE HEART RATE AND RHYTHM AND BLOOD PRESSURE DURING NORMAL RESPIRATORY ACTIVITY AND DURING ARTIFICIAL RESPIRATION AFTER RESPIRATORY ARREST

BENJAMIN H. ROBBINS 1

1 From the Department of Pharmacology, Vanderbilt University School of Medicine Nashville, Tennessee

The concentrations of ether, divinyl ether and cyclopropane necessary in the blood for various levels of anesthesia, and their effects upon the rhythm of the heart and blood pressure have been investigated.

The rhythm of the heart remained normal with ether or cyclopropane under artificial respiration, started at the time of respiratory arrest, until the concentration of these agents in the blood had reached a level of some 30-40% above that at the time of respiratory arrest, whereas with divinyl ether the rhythm was irregular in 6/14 dogs at respiratory arrest and became irregular in 7 more in 1-2 minutes after artificial respiration was started.

The blood pressure is maintained better under cyclopropane anesthesia than under diethyl or divinyl ether.

Submitted on July 12, 1945






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Copyright © 1945 by the American Society for Pharmacology and Experimental Therapeutics.